Regenerative Platelet Rich Plasma Injections for Wrist Osteoarthritis

What is Wrist Osteoarthritis

Orlando, Florida – Wrist osteoarthritis is a “wear and tear” degeneration of the joint surfaces in your wrist. The wrist contains 8 carpal bones that serve as a junction between the other bones of your thumb, hand and forearm. Inflammation can occur at any of these joint surfaces, causing pain and decreased range of motion. Your doctor can make the diagnosis of wrist osteoarthritis by your history, physical examination, and x-rays.

Wrist osteoarthritis can range from mildly irritating to severely debilitating. Gordie Howe, a.k.a. “Mister Hockey,” had to retire from the game because of severe arthritis in his left wrist. Howe is widely regarded as one of the greatest hockey players of all time, but wrist osteoarthritis prematurely ended his career in the National Hockey League.

Regenerative Platelet Rich Plasma Injections for Wrist Osteoarthritis

Wrist Osteoarthritis Treatment

The mainstays of wrist osteoarthritis treatment are activity modification, immobilization, and specific physical therapy exercises. In essence, the goal is to stop the activities that led to the arthritis, perhaps by immobilizing or bracing the wrist with a splint for time, and then performing selective exercises to increase strength, stability, and range of motion. People with moderate or severe wrist osteoarthritis may require steroid injections such as cortisone into the wrist to reduce inflammation. If surgery is necessary, an orthopedic surgeon may perform a proximal row carpectomy, which is a procedure to remove several carpal bones in the wrist. Another more limiting option is a fusion, where the bones of the wrist are fused together so they cannot move relative to one another.

Platelet Rich Plasma Treatment

A newer, non-surgical option for wrist osteoarthritis is the use of platelet rich plasma (PRP). Unlike most medications, platelet rich plasma is produced from a patient’s own blood. A small amount of blood is drawn and spun down to isolate a portion of the blood that contains platelets, growth factors, and other molecules that help facilitate healing. These are the same substances that are circulating in your blood normally; however, the PRP procedure concentrates the substances so they can be reinjected into the arthritic wrist.

People with wrist osteoarthritis at the base of the thumb benefited from platelet rich plasma (PRP) injections in clinical studies. PRP treated individuals had less pain, greater strength, and greater wrist function than those treated with a placebo injection.1 Furthermore, platelet rich plasma improved outcomes in people with osteoarthritis in the carpal bones of the wrist.2

Wrist osteoarthritis is a chronic, painful, degenerative arthritis that limits the range of motion and interferes with work and daily activities. In athletes, wrist osteoarthritis has been career-ending. As with other forms of osteoarthritis, treatment usually starts conservatively, with wrist splints, activity modification, and physical therapy. Physicians may use occasional steroid injections to reduce pain and inflammation. Severe cases of wrist osteoarthritis may require orthopedic surgical treatment. Fortunately, platelet rich plasma therapy may prove to be an additional treatment tool in the physician’s toolbox. While additional research is needed, PRP may be able to help patients delay or avoid invasive treatments such as surgery.


Authored by © The American Regenerative Medicine Society


  1. Loibl M, Lang S, Dendl LM, et al. Leukocyte-Reduced Platelet-Rich Plasma Treatment of Basal Thumb Arthritis: A Pilot Study. Biomed Res Int. 2016;2016:9262909. doi:10.1155/2016/9262909
  2. Steiner MM, Calandruccio JH. Biologic Approaches to Problems of the Hand and Wrist. Orthop Clin North Am. Jul 2017;48(3):343-349. doi:10.1016/j.ocl.2017.03.010